Aurora, Draper Labs, and BAE Team, IBM’s Merger Machine Steams, Lonelygirl15 Beams, & More Deals News

New England firms had a dismal first quarter in terms of securing venture capital investment, but the past week saw a few of them make stabs at turning around Q2, in much the same way the Sox came back to beat the Rangers.

—Stromedix of Cambridge, MA closed a $25 million Series B financing led by New Leaf Venture Partners and joined by Bessemer Venture Partners, Red Abbey Venture Partners, Atlas Venture, and Frazier Healthcare Ventures. Rebecca profiled the 2-year-old startup, which jumpstarted its clinical program by in-licensing drugs from Biogen Idec.

—Boston’s Spark Capital led a $5 million financing round for Los Angeles independent studio Eqal, the firm behind the Longelygirl15 series of YouTube video fame.

—The Defense Advanced Research Projects Agency tapped Aurora Flight Sciences, Draper Laboratories, and BAE Systems, all of which have Bay State operations, under its “Vulture” program to help build a plane that can stay aloft for five years.

—GuildCafe, of Cambridge, MA, announced it had closed a $3 million Series A round from Boston’s Flybridge Capital Partners and was changing its name to GamerDNA as it moves to build a platform that lets gamers record and share their gaming experiences across platforms.

—Regulus, a joint venture between Cambridge, MA-based Alnylam Pharmaceuticals (NASDAQ: [[ticker:ALNY]]) and Isis Therapeutics (NASDAQ: [[ticker:ISIS]]), inked a multi-million-dollar alliance with British pharma giant GlaxoSmithKline to discover, develop, and market therapeutics for inflammatory diseases such as rheumatoid arthritis. Regulus gets $20 million up front, and several hundred million more is on the table.

—Biopharmaceutical company Aileron Therapeutics of Cambridge, which is developing peptide drugs for treating cancer and other diseases, garnered $10 million via a private placement of preferred stock. Apple Tree Partners and the Novartis Venture Fund led the round.

—VisEn Medical of Woburn, MA, raised $5 million in an expanded Series B financing round led by Merck Capital Ventures and Flagship Ventures. The company is developing fluorescence technology for research and medical imaging.

—Wade wrote a fascinating piece that looked at how IBM’s software division makes acquisitions—something it has done 66 times in the last 12 years, often times in Massachusetts. Make that 67, as today Big Blue announced its purchase of Framington, MA-based de-deplication software maker Diligent Technologies.

Author: Robert Buderi

Bob is Xconomy's founder and chairman. He is one of the country's foremost journalists covering business and technology. As a noted author and magazine editor, he is a sought-after commentator on innovation and global competitiveness. Before taking his most recent position as a research fellow in MIT's Center for International Studies, Bob served as Editor in Chief of MIT's Technology Review, then a 10-times-a-year publication with a circulation of 315,000. Bob led the magazine to numerous editorial and design awards and oversaw its expansion into three foreign editions, electronic newsletters, and highly successful conferences. As BusinessWeek's technology editor, he shared in the 1992 National Magazine Award for The Quality Imperative. Bob is the author of four books about technology and innovation. Naval Innovation for the 21st Century (2013) is a post-Cold War account of the Office of Naval Research. Guanxi (2006) focuses on Microsoft's Beijing research lab as a metaphor for global competitiveness. Engines of Tomorrow (2000) describes the evolution of corporate research. The Invention That Changed the World (1996) covered a secret lab at MIT during WWII. Bob served on the Council on Competitiveness-sponsored National Innovation Initiative and is an advisor to the Draper Prize Nominating Committee. He has been a regular guest of CNBC's Strategy Session and has spoken about innovation at many venues, including the Business Council, Amazon, eBay, Google, IBM, and Microsoft.