The Climate for Early-Stage Life Sciences Startups—And 12 Companies Seeking Weather-Proof Investors

3 years to aid development of cancer therapies, cancer imaging technologies, and cancer diagnostics. Beylin said the program, which requires at least a 1:1 match by a third party investor, corporate partner, foundation, state fund, etc., saw a 30 percent spike in applications last December. The first projects funded under the program will be announced soon.

—On the positive side of the ledger, this is great time to hire talented, qualified (even over-qualified) employees in the life sciences. Real estate is also far cheaper. Steinmiller pointed out that space in Cambridge was out of the question for Claros not so long ago. Now it is at least possible. “Not that we want to be in Cambridge,” he quickly added.

—-Entrepreneurs seem to be getting more creative in a down economy. Sandoski said he had seen a doubling of interesting things coming in his door.

—Coming wave of M&A. Big Pharma, medical device companies, and other large concerns are already on the prowl, sensing bargains in cash-strapped startups. Said Sandoski in our pre-conference call, “What I hear from folks is pretty much everybody’s for sale.” Berke, meanwhile, predicted the demise of 30 percent of biotechs and venture firms.

Towards the end of the session, I asked the panelists for take-home advice–should entrepreneurs hold off on their plans in the current climate or plow ahead? No one thought they should put their ambitions on ice, but Berke did say if entrepreneurs are able to incubate their ventures for six months longer in the safe haven of a medical school or university lab, they might find a better climate to come out in.

That said, none of the companies presenting seemed to want to go that route. They were looking for funding—now. Here’s the list of those firms, in alphabetical order, including the university or program each company is associated with, the core contact, and an excerpt of the company’s self description from the conference program (you can find last year’s presenters here):

Acetylon Pharmaceuticals (Harvard University, Dana-Farber Cancer Institute)
Walter C. Ogier, business founder
[email protected]

“Acetylon is focused on development and commercialization of next generation, selective, small-molecule Histone Deacetylase (HDAC) inhibitors with enhanced therapeutic efficacy and tolerability versus current alternatives.”

AugmentRx Medical Technologies (University of Vermont)
Stuart K. J. Smyth, president and CEO
[email protected]

“AugmentRx was created to manufacture, license and market a new class of bioceramic materials that are microporous and are not brittle.”                  

Author: Robert Buderi

Bob is Xconomy's founder and chairman. He is one of the country's foremost journalists covering business and technology. As a noted author and magazine editor, he is a sought-after commentator on innovation and global competitiveness. Before taking his most recent position as a research fellow in MIT's Center for International Studies, Bob served as Editor in Chief of MIT's Technology Review, then a 10-times-a-year publication with a circulation of 315,000. Bob led the magazine to numerous editorial and design awards and oversaw its expansion into three foreign editions, electronic newsletters, and highly successful conferences. As BusinessWeek's technology editor, he shared in the 1992 National Magazine Award for The Quality Imperative. Bob is the author of four books about technology and innovation. Naval Innovation for the 21st Century (2013) is a post-Cold War account of the Office of Naval Research. Guanxi (2006) focuses on Microsoft's Beijing research lab as a metaphor for global competitiveness. Engines of Tomorrow (2000) describes the evolution of corporate research. The Invention That Changed the World (1996) covered a secret lab at MIT during WWII. Bob served on the Council on Competitiveness-sponsored National Innovation Initiative and is an advisor to the Draper Prize Nominating Committee. He has been a regular guest of CNBC's Strategy Session and has spoken about innovation at many venues, including the Business Council, Amazon, eBay, Google, IBM, and Microsoft.