Trius Approaches Next Stage in Drug Development, China Partnerships a Hot Topic at CalAsia, Lpath Headed to Critical Juncture, & More San Diego Life Sciences News

We all look for milestones in life, but several San Diego biotechs are approaching important junctures where they’re expected to report positive results from their drug development studies. Read on to find out which ones, and to catch up on the rest of San Diego’s life sciences news.

—San Diego’s Ardea Biosciences (NASDAQ: [[ticker:RDEA]]) reported some encouraging results last week for the drug it is developing to treat gout. A small number of patients found the drug lowered the amount of uric acid in their blood to acceptable levels within eight days. Still, Ardea is facing increasing competition, since the FDA approved Takeda Pharmaceutical’s gout drug in February and an FDA advisory panel recommended Savient Pharmaceutical’s gout treatment earlier this week.

—Trius Therapeutics CEO Jeff Stein told Luke the company plans to present full results from its recent clinical trial of a new antibiotic for treating MRSA at a conference in September. The startup also is working on a pivotal clinical trial strategy, and it is searching for a potential partner.

—San Diego’s Biocom, the life sciences industry trade group, hosted the CalAsia conference for the first time this week, and more than 300 representatives of the international biotech community attended. In a Q&A with Xconomy, Dr. Hui Cai of Inflexion BioPartners discussed the concerns that U.S. companies have about doing business in China—and China’s concerns about doing business with U.S. companies. In an e-mail yesterday, she adds, “A consensus out of CalAsia is [that] the line between U.S. and Asia certainly is becoming fuzzy. Gaps we see today in knowledge, processes, and other aspects will eventually disappear, and global standards will be established.”

—San Diego’s Lpath is nearing a make-or-break milestone in its development of sonepcizumab, an experimental cancer drug. The biotech stands to receive up to $8 million from Merck Serono for achieving performance targets related to the clinical trial Lpath is wrapping up, and an additional $31 million if the Swiss pharmaceutical company exercises an option to develop the drug.

—San Diego-based aFraxis, which is focused on developing treatments for Fragile X syndrome and autism, has raised $750,000 in early stage funding, according to a recent SEC filing. The startup is backed by San Diego’s Avalon Ventures, and Avalon’s Jay Lichter is listed as chief executive and director.

—Illumina, the San Diego biotech that provides DNA research tools for scientists, plans to offer a service that will enable consumers to get their DNA sequenced—at a cost of $48,000. As expensive as that may sound, it is half as much as the DNA sequencing service offered by Cambridge, MA-based Knome. The idea is to give patients access to comprehensive, personalized information about their vulnerability to disease.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.