[Editor’s Note: As the decade comes to an end, we’ve asked a number of Xconomists around the country to weigh in with the Top 5 innovations they’ve seen in their respective fields the past 10 years, or the Top 5 disruptive technologies that will impact the next decade. Here’s the first installment.]
Here are the 5 biotech innovations from this decade that are currently (or will be shortly) making a big difference for patients with a variety of diseases.
1) Cancer therapies such as Roche/Genentech’s trastuzumab (Herceptin) and Celgene’s lenalidomide (Revlimid).
2) HIV therapies such as Gilead Sciences’ combination of efavirenz, emtricitabine, and tenofovir (Atripla).
3) Improved flu vaccines.
4) Therapies for hepatitis C such as Vertex Pharmaceuticals’ telaprevir.
5) Tumor vaccines such as Dendreon’s sipuleucel-T (Provenge).
Author: Clay Siegall
Clay Siegall co-founded Seattle Genetics in 1998 and is the company’s President, Chief Executive Officer and a member of the Board of Directors. Seattle Genetics is developing a diverse portfolio of clinical and preclinical product candidates targeting a variety of cancer and autoimmune indications. The company is also a leader in antibody technologies, notably its antibody-drug conjugate (ADC) platform. Dr. Siegall has guided Seattle Genetics’ capital-raising activities, securing more than $330 million through public and private financings, including the company’s initial public offering in 2001. In addition, the company has entered into multiple strategic collaborations, including an exclusive worldwide collaboration agreement with Genentech for SGN-40 valued at more than $860 million, and several ADC collaborations including with Genentech, MedImmune, CuraGen, Bayer and Progenics that have generated more than $65 million since 2001.
Prior to co-founding Seattle Genetics, Dr. Siegall was with the Bristol-Myers Squibb Pharmaceutical Research Institute from 1991 to 1997 and the National Cancer Institute, National Institutes of Health from 1988 to 1991. He serves on the Board of Directors of Alder BioPharmaceuticals, a private biotechnology company, and the Washington Biotechnology and Biomedical Association (WBBA), as well as on the Board of Governors of the Fred Hutchinson Cancer Research Business Alliance. He received a Ph.D. in Genetics from George Washington University and a B.S. in Zoology from the University of Maryland.
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