Biotech Entrepreneurs Offer Tips For Winning an SBIR—Including a Top 10 List of Dos and Don’ts

The latest organization to spring fully formed from the brow of San Diego’s Life Sciences community was not Athena, but the San Diego Entrepreneurs Exchange, which Denise profiled in March when the SDEE was preparing to hold its first meeting.

I’d guess close to 140 people turned out earlier this week for the group’s second meeting, which was organized around a case study presentation and discussion among local biotech entrepreneurs who were successful in winning Small Business Innovation Research (SBIR) grants from the National Institutes of Health. These are small grants. David Larocca, the founder, CEO, and principle scientist of Mandala Biosciences, says a Phase I SBIR “proof of principle” grant is usually limited to $150,000, while a Phase II “commercialization” grant is typically limited to $1.2 million.

But even the smaller figure might be enough to help an early stage biotech survive. Although SDEE’s focus was on SBIRs awarded through the NIH, the Pentagon also awards a big chunk of SBIR grants. (Some local tech entrepreneurs previously talked about their experience here.) SDEE founder and Orphagen CEO Scott Thacher says he founded the SDEE for biotech entrepreneurs like himself who are unlikely to get venture capital funding for their early stage startups. “We try to attract entrepreneurs or people who have lost their jobs or who are trying to get their company to the next level,” Thacher says.

John Finn, the chief scientific officer of Trius Therapeutics, says life sciences startups can’t live by SBIRs alone. In his case study presentation about the early years of Trius, Finn says he potentially saved millions of dollars by acquiring

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.