Conatus Gets Idun, Trius Goes Public, BrainCells Gets Sabcomeline, & More San Diego-Area Life Sciences News

Either I have too much time on my hands, or the first half of today’s headline is pretty close to a Haiku in English. Don’t grade me. Let’s just move on with the roundup of life sciences news.

—We briefly noted that San Diego’s Conatus Pharmaceuticals acquired Idun Pharmaceuticals for an undisclosed sum from Pfizer, which has been operating the San Diego-based subsidiary since 2005. But PE Hub’s Dan Primack cogently unraveled how Conatus, which was formed by executives who left Idun, likely paid less than 10 percent of what Pfizer paid to acquire Idun just five years ago.

—Plans by Complete Genomics to raise as much as $86 million through an IPO could lead to a payout for San Diego’s Enterprise Partners Venture Capital, which is among several VCs that invested in the Mountain View, CA, company. Complete Genomics has been developing its own methodology for inexpensive gene sequencing.

—Carlsbad, CA-based Isis Pharmaceuticals (NASDAQ: [[ticker:ISIS]]) and Cambridge, MA-based Genzyme (NASDAQ: [[ticker:GENZ]]) said their drug for people with severely high cholesterol passed a pair of key clinical trials. The companies are preparing to seek clearance from regulators next year to begin selling the drug in the U.S. and Europe.

—Ryan talked with two former Vertex Pharmaceuticals (NASDAQ: [[ticker:VRTX]]) executives, Roger Tung and Rich Aldrich, to unravel how Eli Lilly walked away from nearly its entire stake in the drug telaprevir, the hepatitis C treatment that is nearing approval as a treatment for the chronic liver disease. Today, telaprevir represents a potential multibillion-dollar molecule for Cambridge, MA-based Vertex, which has significant operations in San Diego.

—OK, the Trius Therapeutics IPO was ugly—but the important thing is it got done. The San Diego biotech, which is developing technology to create a class of new antibiotic compounds, raised about $49 million instead of $78 million it had hoped to rake in through its IPO. After postponing its IPO for months earlier this year, Trius (NASDAQ: [[ticker:TSRX]]) cut its share price and increased the number of shares shortly before the offering.

—San Diego’s Optimer Pharmaceuticals (NASDAQ: [[ticker:OPTR]]) filed an application to start marketing fidaxomicin in the European Union as a treatment for C.difficile bacterial infections. Optimer plans to seek FDA approval later this year.

—San Diego’s BrainCells Inc. agreed to pay as much as $51 million to acquire a drug, sabcomeline, from London-based Proximagen that could have potential against various psychiatric diseases.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.