San Diego’s Ligand Takes Advantage of the Great Recession to Build New Drug Pipeline

strategy under John Higgins, a onetime investment banker who was named CEO in January 2007. Instead of swinging for the fences—and consuming extensive corporate resources on drug discovery, development, and sales and marketing—Higgins has focused on generating more chances at bat by acquiring dozens of new drug candidates, on keeping costs low, and on forming drug development partnerships as soon as possible.

Ligand CEO John Higgins

Higgins, who was brought in by dissident shareholders (including Dan Loeb of New York-based Third Point Management) from Palo Alto, CA-based Connetics, says Ligand had some “good assets” in its drug pipeline, but there had been “a shameful waste of assets in terms of overfunding programs.” He also voiced dismay that Ligand never made money in the years that Robinson headed Ligand—“with a veteran board and management team who were too caught up in their own expectations or egos to change course.”

And then there is a nearly three-year period—from 2002 through most of 2004—that Higgins described as “a miserable period from an accounting and financial reporting point of view.” With revenue in four consecutive quarters overstated by $100 million, Ligand’s restatement of its financial reports came with a massive investigation by the Securities and Exchange Commission. The SEC ultimately terminated its probe of Ligand with no enforcement action, but “it was a very, very messy, ugly investigation,” Higgins says. “This was a broken company. The shareholders wanted to get this thing focused and disciplined, and that’s why they hired me.”

Higgins was fortunate in one respect. Before he took over, Ligand already had begun cleaning house under then-chairman and CEO Henry F. Blissenbach. It was Blissenbach who carried out many of the unpleasant tasks, in terms of shedding

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.