West Coast Biotech Roundup: Audentes, Fate, Zosano & More

Oregon Coast near Canon Beach (CC-photo-credit-Kay-Gaensler)

When 23andMe said Wednesday it had raised $115 million in a new venture capital round, Reuters reported that the round implied a total valuation of $1.1 billion for the genomics company—making 23andMe a new member of the rare and wondrous (and growing) unicorn club. (The Wall Street Journal has listed the Mountain View, CA-based company on its billion-dollar startup list since June, and CB Insights added 23andMe to its unicorn list in July, but no matter.)

Silicon Valley’s technorati define “unicorn” as a private technology startup valued at more than $1 billion, and 2015 is already a record year for newborn unicorns. Of the 142 companies on CB Insights’ global unicorn list, 66 were added in the first nine months of 2015 (including companies like Lynda.com, which became a unicorn before exiting). According to CB Insights’ latest report, the 66 new unicorns include 39 U.S.-based companies.

But unicorns aren’t just for tech companies any more. There are now 10 life sciences companies on CB Insights’ list, including Theranos (valued at $9 billion, with some controversy here), Intarcia Therapeutics ($5.5B), Stemcentrx ($3B), Moderna ($2B), and NantHealth ($2B).

Xconomy’s Alex Lash has argued, “Biotechs, being the home of disciplined scientists (we hope), should have a more reality-based buzzword. From here on out, billion-dollar biotechs are snow leopards, and the preclinical ones that manage an IPO are coelacanths—so rare that people once thought they only existed millions of years ago.”

In a note yesterday, he adds, “When you study biology and chemistry all day instead of trying to create the next reality distortion field, you tend not to put much stock in mythological life forms.”

In other life sciences news:

—San Francisco’s Audentes Therapeutics, which is focused on commercializing gene therapy products for serious and rare diseases, said Tuesday it raised $65 million in a Series C financing led by Sofinnova Ventures, an existing investor, Redmile Group, a new investor. Audentes said proceeds would be used mostly to advance its three lead development programs and to establish internal manufacturing capabilities.

LeafBio, the commercial arm of San Diego’s Mapp Biopharmaceutical, said today the European Medicines Agency has given the Ebola drug ZMapp its “Orphan Medicinal Product Designation.” The agency uses the designation to encourage the development of drugs and other products targeting rare diseases with no existing cure or treatment. The designation provides such benefits as protocol assistance and market exclusivity.

—A new Global Health Vaccine Center of Innovation will be housed at Seattle’s Infectious Disease Research Institute (IDRI). The center, with funding from Sanofi Psteur and the Bill & Melinda Gates Foundation, aims to accelerate vaccine development for global infectious disease, and to ensure their accessibility. The center also plans to collaborate with other vaccine developers.

—The human genome pioneer J. Craig Venter invited VIPs and reporters to tour Health Nucleus, a new business venture that uses whole genome sequencing, microbiome sequencing, advanced medical imaging, and other diagnostics for elite, self-paying customers. The proposal triggered some skepticism among the Twitterati; you can follow their comments here.

—The biotech accelerator IndieBio says it’s enrolling a new class of 15 startups at its

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.