3 Boston VCs Share Investment Themes for 2016

standalone opportunities—products like Fitbits or a smart pill bottle that reminds you to take your meds, or a variety of apps on your phone. Whatever the case, says Callow, “The retention rate falls off after about 90 to 120 days.”

Callow is looking to invest in companies that will change this paradigm. He doesn’t think success will come from some breakthrough device. Rather, he thinks it is about mastering the psychological or social skills of getting people to stick to the plan. In short, he says, “We have concluded it probably is a service business, not a product business.”

One company in Callow’s portfolio that addressed at least a piece of the compliance issue was Boston-based PHT Corp., which sold in early 2015 to ERT of Philadelphia. Among other things, PHT developed software and apps that let patients self-report on the outcomes of their treatment—an important component of the Affordable Care Act that figures into how hospitals, drug companies, and others are reimbursed.

Underserved Customers and Weird and Wonderful Spaces in Unusual Places – Eric Paley, Founder Collective

One of the more eclectic approaches to venture investing likely comes from Founder Collective. As Eric Paley puts it, “we’re stage focused and sector agnostic—we love seed stage deals, no matter if they’re trying to build “Keurig for Wine” (Kuvee), a new kind of propulsion system for micro-satellites (Accion Systems ), or a service that connects publishers, authors, and book lovers” (BookBub).

EricPaleyBut that doesn’t mean there isn’t a plan or philosophy. Here are a few of the thematic principles guiding the firm in 2016.

Underserved Customers—In the past year or so, says Paley, “We’ve backed companies bringing the Internet of Things to pharma labs, a plus-sized fashion ecommerce company, and a food delivery service that targets second-tier cities.”

The common element behind all these companies, says Paley: “The founders are obsessed with the idea of serving customers that no one else cares about.” In fact, he says, none of these companies have real competitors to speak of, even though their target markets are worth nearly $200 billion dollars. And that is not an unusual circumstance, he says. “There are entire industries that are being ignored and we want to back founders who disrupt them.”

Weird and Wonderful Spaces in Unusual Places—I had to save this one for last. Here is how Paley describes the idea:

“While Uber is the dominant company in tech right now, when we invested in 2009 it was more of a curiosity. It has no relationship to our other portfolio company, BuzzFeed, which is nothing like PillPack’s robotic pharmacies, both of which are completely different from Coupang, which is the largest ecommerce company in South Korea (and one of only 5 startups to raise a billion dollars in a single round of funding).

“Basically, if what you’re working on scares other VCs, we’d love to learn more.”

Author: Robert Buderi

Bob is Xconomy's founder and chairman. He is one of the country's foremost journalists covering business and technology. As a noted author and magazine editor, he is a sought-after commentator on innovation and global competitiveness. Before taking his most recent position as a research fellow in MIT's Center for International Studies, Bob served as Editor in Chief of MIT's Technology Review, then a 10-times-a-year publication with a circulation of 315,000. Bob led the magazine to numerous editorial and design awards and oversaw its expansion into three foreign editions, electronic newsletters, and highly successful conferences. As BusinessWeek's technology editor, he shared in the 1992 National Magazine Award for The Quality Imperative. Bob is the author of four books about technology and innovation. Naval Innovation for the 21st Century (2013) is a post-Cold War account of the Office of Naval Research. Guanxi (2006) focuses on Microsoft's Beijing research lab as a metaphor for global competitiveness. Engines of Tomorrow (2000) describes the evolution of corporate research. The Invention That Changed the World (1996) covered a secret lab at MIT during WWII. Bob served on the Council on Competitiveness-sponsored National Innovation Initiative and is an advisor to the Draper Prize Nominating Committee. He has been a regular guest of CNBC's Strategy Session and has spoken about innovation at many venues, including the Business Council, Amazon, eBay, Google, IBM, and Microsoft.