JLABS Takes Stock of Its Experiment in Life Sciences Innovation

JLABS San Diego (JLABS photo used with permission)

its “no strings attached” policy, JLABS reports that its startups have executed deals with at least a dozen outside venture funds, as well as with Merck, Novartis, Bayer, Bristol-Myers Squibb, and other life sciences giants. Having a front-row seat also has its perquisites, though, as 71 startups have signed deals (sometimes multiple deals) with the Johnson & Johnson family of companies. (Seven JLABS resident companies have collaborated with each other.)

—Five JLABS startups have gone on to initial public offerings: Audentes Therapeutics (NASDAQ: [[ticker:BOLD]]) (out of the South San Francisco site) raised $75 million and SillaJen (San Francisco at QB3) raised about $135 million in its IPO in South Korea. Three IPOs came out of JLABS San Diego: Cidara Therapeutics (NASDAQ: [[ticker:CDTX]]) raised $77 million; Sienna Biopharmaceuticals (NASDAQ: [[ticker:SNNA]]) raised $65 million; and Mirati Therapeutics (NASDAQ: [[ticker:MRTX]]) raised almost $60 million through a restructuring.

—Another eight JLABS companies have been acquired, including Cambridge, MA-based Padlock Therapeutics (acquired by Bristol-Myers Squibb for as much as $600 million), Silicon Biosystems (acquired by Italy’s Menarini Group), and Tem Systems (acquired by Instrumentation Laboratory).

Richter, who joined Johnson & Johnson Innovation after initially managing JLABS as an outside contractor, said JLABS “has taken a very tech-oriented approach” to its operations. “We don’t wait for a big panacea solution. You take a step and see how it goes, experiment and see how it goes. For us, it’s just a constant journey of acting, learning, iterating.”

As an example, Richter said JLABS has created a series of QuickFire Challenge competitions as a kind of crowd-sourcing approach for identifying potential technologies and solutions for a variety of healthcare issues. The company has launched 22 QuickFire Challenges so far, including one that offers as much as $100,000 in grants and one year of free JLABS residence to teams that submit the best ideas, technologies, or solutions for using artificial intelligence to advance drug discovery.

One of the stats that Richter said she is most proud of is that 23 percent of JLABS companies are led by a female CEO, and 18 percent are led by under-represented ethnic minorities. “We put a focus on that, it’s something we support,” Richter said.

Gender diversity has been a hot topic in the industry in recent years, and the focus on women at JLABS “is absolutely a step in the right direction,” said Karl Simpson of LiftStream, a life sciences executive recruiting and consulting firm that has looked at gender diversity in the United States and Europe. Simpson estimates that somewhere between 7 and 9 percent of life sciences CEOs are women, a disparity he attributes chiefly to corporate culture and an accumulation of other factors.

For the life sciences companies that start at JLABS, Simpson said, the challenge is whether those higher percentages of top female executives carry through as startups mature and grow into bigger corporate organizations. “Raising capital as a female CEO is very difficult because men dominate the venture capital industry,” Simpson said. “Boards also tend to be male-dominated. So the question tends to be whether they can go the distance.”

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.