San Diego’s Arcturus Raises $5M for “Best-in-Class” RNAi Technology

San Diego’s Arcturus Therapeutics, founded earlier this year to advance RNA interference (RNAi) technology, says it has secured $5 million in a Series A round raised entirely from individual investors in the United States and abroad.

Pad Chivukula, a co-founder, COO, and chief scientific officer, writes in an e-mail that raising that much from private investors (with 90 percent of the seed investors returning) “is almost impossible these days.” Arcturus raised its seed funding in June, and the latest round brings the cumulative total to $6.3 million.

With the new funding, Chivukula says Arcturus plans to nominate its first clinical candidate in 2014 and recruit key personnel, including a business development executive “from one of the large nucleic acid delivery companies.”

Arcturus is based at the Janssen Labs on Torrey Pines Mesa (which was established to help incubate early stage life sciences startups), but that could change as the company grows. Chivukla says the startup now has 10 employees and, “in the near term we are going to add quite a few employees.”

Arcturus Therapeutics, RNA interferenceIn a statement yesterday, Arcturus says it anticipates additional revenues will be generated next year from the portfolio of Unlocked Nucleic Acid (UNA) analogs the company acquired two months ago from Marina Biotech of Bothell, WA. Arcturus says the U.S. Patent and Trademark Office recently granted “very broad claims” for the UNA portfolio.

Following decades of development, RNAi has been emerging as one of the most-promising life sciences technology platforms for treating a

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.