Long Courtship Preceded GlaxoSmithKline’s Sirtris Acquisition

GlaxoSmithKline’s purchase of Cambridge, MA-based Sirtris Pharmaceuticals—a deal completed today—was on the drawing boards long before it made headlines in late April, according to an interesting story by Boston Globe reporter Todd Wallack.

“We’re getting married to someone that we’ve been dating for a while,” Sirtris CEO Christoph Westphal told Wallack.

Sirtris, which went public just last year, is developing drug candidates that treat conditions such as diabetes and cancer by activating sirtuins, a class of proteins in the body that are involved in regulating metabolism and lifespan. GlaxoSmithKline, headquartered in London and Philadelphia, was attracted to the company because sirtuin research could help round out its pipeline of drugs for metabolic, neurological, immunological, and inflammation-related disorders.

Wallack’s article, which is based on SEC filings and interviews with Westphal, says that talks last August between the two companies about a possible GSK investment in Sirtris quickly evolved into merger discussions. In early April, GSK offered $18.50 to $19.50 per share for the company, Wallack reports, but Sirtris was able to talk the pharmaceutical giant up to $22.50 per share, or $720 million.

That will produce a nice windfall for Westphal himself (who stands to earn up to $25 million from the acquisition), for venture investors Polaris Venture Partners and Cardinal Partners, and for a lineup of prominent Bostonians that includes Red Sox owner John Henry, former Fidelity money manager Peter Lynch, Celtics manager Wyc Grousbeck, and former U.S. Congressman Joseph P. Kennedy II.

The acquisition agreement calls for Sirtris to remain an autonomous unit within GSK for three years, and GSK has offered Westphal a $2 million bonus incentive if he stays on for at least four years, according to Wallack.

Author: Wade Roush

Between 2007 and 2014, I was a staff editor for Xconomy in Boston and San Francisco. Since 2008 I've been writing a weekly opinion/review column called VOX: The Voice of Xperience. (From 2008 to 2013 the column was known as World Wide Wade.) I've been writing about science and technology professionally since 1994. Before joining Xconomy in 2007, I was a staff member at MIT’s Technology Review from 2001 to 2006, serving as senior editor, San Francisco bureau chief, and executive editor of TechnologyReview.com. Before that, I was the Boston bureau reporter for Science, managing editor of supercomputing publications at NASA Ames Research Center, and Web editor at e-book pioneer NuvoMedia. I have a B.A. in the history of science from Harvard College and a PhD in the history and social study of science and technology from MIT. I've published articles in Science, Technology Review, IEEE Spectrum, Encyclopaedia Brittanica, Technology and Culture, Alaska Airlines Magazine, and World Business, and I've been a guest of NPR, CNN, CNBC, NECN, WGBH and the PBS NewsHour. I'm a frequent conference participant and enjoy opportunities to moderate panel discussions and on-stage chats. My personal site: waderoush.com My social media coordinates: Twitter: @wroush Facebook: facebook.com/wade.roush LinkedIn: linkedin.com/in/waderoush Google+ : google.com/+WadeRoush YouTube: youtube.com/wroush1967 Flickr: flickr.com/photos/wroush/ Pinterest: pinterest.com/waderoush/