Venture Funding Looms Large for San Diego Biopharma Startups

Correlation Ventures co-founder and managing director

Venture capital funding in the San Diego area has recovered from a three-year plunge that accompanied the U.S. financial crisis, according to a recent analysis of a decade’s worth of VC deals.

But venture investments in San Diego remain heavily concentrated in new drug startups, according to David Coats, the San Diego-based co-founder and managing director of Correlation Ventures. “The San Diego venture ecosystem looks very different than the rest of the industry,” Coats said in a recent presentation to the San Diego Venture Group.

Correlation Ventures, based in San Diego and Palo Alto, CA, has amassed a proprietary database of more than 60,000 venture financing deals, with details on the Correlation Ventures logoinvestors, valuations, companies, and startup team in every deal. The database is central to its investment strategy, which uses predictive analytics to assess the risk of each prospective deal by searching for key variables that correlate with the details of successful outcomes in its database.

Using the database, Coats gleaned some new insights about venture deals from 2004 through 2013—and how San Diego compares with the U.S. venture industry.

“During the recession, we were hit harder in terms of total venture dollars going into the region,” Coats said. “We have recovered since then, but we are not well-diversified.”

In the years leading up to the Great Recession, which officially began in 2007, venture investments in San Diego amounted to about 6 percent of the U.S. total, according to Correlation Ventures’ data. That dropped to just 3 percent of the

San Diego VC Trends (Correlation Ventures)

nationwide total over the next three years. Venture funding levels began to recover in 2010, and returned to 6 percent of the U.S. pie in 2013.

The data show that venture funding for biopharmaceutical startups accounts for the lion’s share of VC deals in San Diego. In fact, funding for San Diego’s biopharma sector account for 42 percent of venture investments in all U.S. biopharma deals from 2004 through 2013.

That should come as no surprise, as the biotech sector has dominated venture activity in San Diego since Hybritech burst onto the scene in the early 1980s.

Market conditions also have enabled the life sciences sector to flourish in recent years, and venture-backed biopharma companies have led the stampede of IPOs in the past two years.

The biopharma concentration in San Diego “is not necessarily a bad thing,” said Coats, who oversees the firm’s life sciences deals. “Like a company, you want to focus on the areas where you have a competitive advantage.”

Still, he noted that biopharma venture funding has been declining in both San Diego and nationwide. (In 2004, biopharma investments in San Diego were close to 55 percent of the industry total.) Beyond the biopharma sector, though, San Diego doesn’t have much to brag about in terms of venture funding.

SD biopharma funding (Courtesy Correlation Ventures)

While San Diego-based Qualcomm (NASDAQ: [[ticker:QCOM]]) has emerged as the world’s biggest wireless technology company,  the flurry of local telecom and networking startups that followed industry deregulation in 1996 has largely died out. Today, the Correlation data shows that San Diego lags the industry average for VC investments in most sectors of venture-backed innovation, including hardware/communications, software, business and financial technologies, and consumer services.

One pleasant surprise to emerge from the data is that the company valuations in the top 10 percent of venture-backed exits were higher in San Diego in comparison to the overall industry. From 2004 to 2013, San Diego companies in the top tier carried an average valuation of $315 million at exit, compared with an industry-wide average valuation of $240 million for companies in all sectors.

Below the top tier, though, average company valuations over the decade were slightly lower in San Diego—$94 million—than the industry average of $104 million.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.