Anadys Moves Hepatitis C Drug Ahead on its Own, Intellikine Casts a Broad Net, Sequel Pharma Raising $8.4M, & Other San Diego Life Sciences News

It’s been relatively slow for San Diego life sciences news, except for a flurry of funding deals for local drug development companies. Get the scoop on who’s getting money, along with some biotech profiles and more.

—CEO Steve Worland of San Diego’s Anadys Pharmaceuticals (NASDAQ: [[ticker:ANDS]]) says the company has stabilized following some mercurial advances and declines in the price of its shares. Whether or not Wall Street has been overreacting to Anadys’ announcements concerning its experimental drug for treating hepatitis C, Worland has put his efforts to find a drug development partner on hold. Instead, he’s cut payroll and raised more than $16 million so the company can carry out the next stage of its drug development plan on its own.

—One of the most ambitious life sciences startups in San Diego nowadays is Intellikine, a two-year-old drug development company that has raised $28 million this year of what could be as much as $51 million in venture capital. Intellikine co-founder and CEO Troy Wilson told Luke Intellikine company is developing drugs to block what’s known as the PI3 kinase pathway, reactions that control cell proliferation, migration, and survival. It’s a hot area because researchers have shown the pathway is involved in both cancer and autoimmune diseases.

Several life sciences companies in the region have been busy raising capital, according to some recent filings with the federal Securities and Exchange Commission. Vista, CA-based Auspex Pharmaceuticals, which specializes in the emerging field of deuterium modification, says it raised $3 million in warrants and promissary notes that can be converted to shares of preferred stock. San Diego-based Palkion, which is developing drugs to treat anemia, has raised $2.5 million from investors. And San Diego-based Sequel Pharmaceuticals, which is developing drugs to treat a type of irregular heartbeat known as atrial fibrillation, has raised about $3 million of a planned $8.4 million round.

—Seattle biotech consultant Stewart Lyman submitted a national post that describes how the life sciences industry has entered the era of biologics—genetically engineered protein drugs made in living cells. Lyman says Big Pharma views the development of new biologics-based drugs as a smart move because generic versions of biologics-based drugs are expected to raise more concerns among regulators than generic copies of their traditional small-molecule treatments. That means generic versions of biologics appear more likely to withstand competition from generics that has done so much to undermine sales of conventional drugs.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.