Targanta Therapeutics Sets IPO Terms—Could Make for Nice Comeback for Firm’s CEO

Targanta Therapeutics, a Cambridge biopharmaceutical company focused on developing antibiotics to combat serious infections, today set the terms of its impending IPO, announcing plans to sell 5.75 million shares of common stock at between $12 and $14 a share. In the mid-range of the pricing, after commissions, discounts, and other expenses, the company said it expects to realize net proceeds of about $68 million.

Targanta acquired the rights to its lead product, oritavancin, in 2005. According to its SEC filing, the company believes it has enough data to support FDA approval of the drug for its first indication (complicated skin infections), and hopes that approval will come in late 2008.

A successful Targanta IPO would herald a great comeback for its CEO Mark Leuchtenberger, who just over a year ago (in June 2006) announced the demise of his previous company, Cambridge-based Therion Biologics, after its two lead products—both cancer vaccines—failed to meet expectations in clinical trials. Therion, where Leuchtenberger served as President and CEO, was a high-flyer that took in more than $120 million in three rounds of financing, much of it from German billionaire Hans-Werner Hector, a co-founder of the software firm SAP. After the disappointing trials, Hector cut off a $50 million line of credit he had extended to the company, according to Mass High Tech.

Leuchtenberger, who headed the Massachusetts Biotechnology Council search committee that recently tapped Robert Coughlin as the new MBC president, has said in the past that he learned a painful lesson with Therion—never to be so dependent on one source of financing. If successful, the IPO, coupled with a $70 million round of venture financing earlier in the year, should help with that.

Author: Robert Buderi

Bob is Xconomy's founder and chairman. He is one of the country's foremost journalists covering business and technology. As a noted author and magazine editor, he is a sought-after commentator on innovation and global competitiveness. Before taking his most recent position as a research fellow in MIT's Center for International Studies, Bob served as Editor in Chief of MIT's Technology Review, then a 10-times-a-year publication with a circulation of 315,000. Bob led the magazine to numerous editorial and design awards and oversaw its expansion into three foreign editions, electronic newsletters, and highly successful conferences. As BusinessWeek's technology editor, he shared in the 1992 National Magazine Award for The Quality Imperative. Bob is the author of four books about technology and innovation. Naval Innovation for the 21st Century (2013) is a post-Cold War account of the Office of Naval Research. Guanxi (2006) focuses on Microsoft's Beijing research lab as a metaphor for global competitiveness. Engines of Tomorrow (2000) describes the evolution of corporate research. The Invention That Changed the World (1996) covered a secret lab at MIT during WWII. Bob served on the Council on Competitiveness-sponsored National Innovation Initiative and is an advisor to the Draper Prize Nominating Committee. He has been a regular guest of CNBC's Strategy Session and has spoken about innovation at many venues, including the Business Council, Amazon, eBay, Google, IBM, and Microsoft.