Cypress Bio Gets Buyout Offer, Trius Prepares for IPO, Arena Gains Following Vivus Setback, & More San Diego Life Sciences News

San Diego’s life sciences companies continued to raise big money, which is a good thing, since a survey shows that venture funding for biotech and medical device companies accounted for more than 80 of all second-quarter VC deals in San Diego. We’ve rounded up all that and more for you here:

—San Diego’s Cypress Bioscience (NASDAQ: [[ticker:CYPB]]) said its board will review an unsolicited buyout offer with its financial and legal advisers, and advised the company’s shareholders to “take no action at this time.” New York-based Ramius, a $7.8-billion hedge fund group, owns almost 10 percent of Cypress and offered $4 a share, or about $160 million, to acquire the rest.

—San Diego-based Trius Therapeutics is back on track after it was forced to postpone its planned IPO earlier this year to accommodate new FDA guidelines for a late-stage trial of its antibiotic. The company’s initial stock offering is expected next week.

An expert panel that advises the FDA voted 10-6 against approving an obesity drug developed by Mountain View, CA-based Vivus (NASDAQ: [[ticker:VVUS]]), saying the negative effects outweighed the weight-loss benefits. After the ruling, shares of San Diego’s Arena Pharmaceuticals (NASDAQ: [[ticker:ARNA]]) climbed toward its 52-week high of $5.93 a share, but San Diego-based Orexigen Therapeutics (NASDAQ: [[ticker:OREX]]) continued to trade around $4 a share. Both San Diego biotechs are developing obesity drugs of their own.

—Alzheimer’s drug developer Sonexa Therapeutics ranked as San Diego’s No. 1 venture deal during the second quarter, when the biotech raised $37.23 million. The MoneyTree survey showed that venture firms invested $170.6 million in 24 local companies during the quarter—with more than 80 percent of the capital going to life sciences deals.

—San Diego-based Zogenix, a four-year-old startup developing drugs for treating neuroscience disorders and pain, said last week it raised $50 million in an undesignated round that includes a $15 million venture investment from its existing investors and $35 million in debt financing led by Oxford Finance and Silicon Valley Bank. The returning venture investors are Clarus Ventures, Domain Associates, Scale Venture Partners, Thomas, McNerney & Partners, Abingworth Management, and Chicago Growth Partners.

—San Diego authorities have charged a 59-year-old man, Kent Thomas Keigwin, with murder in connection with the death of John G. Watson, a retired biotech executive and angel investor who was found dead in his La Jolla home on June 8. Prosecutors said Keigwin also was charged with identity theft, grand theft of personal property, burglary, and forgery of documents in connection with $7.5 million that was unlawfully transferred from Watson’s brokerage account.

Auspex Pharmaceuticals of Vista, CA, has raised an additional $12 million from investors to continue development of deuterium-based analogs of clinically validated drugs in multiple therapeutic areas. The biotech raised almost $13.9 million in a previous round from Thomas, McNerney & Partners, CMEA Ventures, and Costa Verde Capital.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.