Life Wants Ion Torrent for Fast Gene Sequencing, Biogen-Idec Takes On Lou Gehrig’s Disease, Two Biotechs Move Toward IPOs, & More San Diego Life Science News

Whatever happened to the lazy “dog days of summer?” The past week was busy with life science news, with a lot of deals and other developments. Here’s our summary:

—Carlsbad, CA-based Life Technologies (NASDAQ: [[ticker:LIFE]]), in a bid to gain a competitive advantage in the market for fast and cheap gene sequencing, acquired Ion Torrent Streams of Guilford, CT, and South San Francisco, CA, for $375 million in cash and stock. Ion Torrent could get another $350 million in cash and stock if it can meet certain technical milestones through 2012. Game on!

—San Diego’s Cypress Bioscience (NASDAQ: [[ticker:CYPB]]) disclosed in a regulatory filing that one of its independent directors, Jean-Pierre Millon, has resigned. The director’s departure comes while Cypress Bio has been trying to hold off Ramius Value and Opportunity Advisors, which made an unsolicited $160 million buyout offer that Cypress has repeatedly rejected.

—Weston, MA-based Biogen Idec (NASDAQ: [[ticker:BIIB]]) landed a deal with Knopp Neurosciences to develop an experimental drug for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. Biogen, which has significant operations in San Diego, provided $20 million in an upfront payment to Pittsburgh-based Knopp, and purchased $60 million in Knopp stock. Knopp also could get another $265 million in Biogen payments tied to drug development goals.

—San Diego-based Allylix, which raised $9 million in venture funding in April, has launched its first terpene product—called nootkatone. It’s a flavor-fragrance that could be described as essence of grapefruit. As Allylix introduces new products to market, it’s gaining visibility as the latest of a new kind of startup that is using biotechnology to make “renewable chemicals” that take the “petro” out of petro-chemicals.

—I profiled San Diego’s Zogenix, which has raised $199 million since it was founded four years ago, and won FDA approval for its combined migraine drug and needle-free delivery system in mid-2009. Zogenix says its DosePro device is a faster and simpler method for subcutaneous injections than existing hypodermic needles and other devices.

—San Diego’s Prometheus Laboratories has amended the IPO registration it has had on file with government regulators since 2007. The specialty pharma and diagnostics company has not priced its shares, but is expected to raise somewhere between $100 million and $150 million.

—I talked with Ken Widder, the San Diego-based partner in San Francisco’s Latterell Venture Partners. He told me the firm doesn’t usually take management positions in the companies it helps create. But Widder said the partners have extensive operating experience and bring lots of practical talent to the startup boards they sit on. Widder, for example, has founded seven life science companies, holds 30 patents or patent filings, and has authored or co-authored 25 scientific papers.

—San Diego’s Reva Medical, which has been developing bioabsorbable medical stents, has filed for a $63 million IPO on the Australian Stock Exchange.

—San Diego’s Biocept, which has been adopting micro-fluidic technology to the field of cancer diagnostics, has raised $2.3 million of a planned $7.1 million round of equity funding.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.