Two preclinical programs developed by Canadian biotech Northern Biologics have been acquired by privately held German company Boehringer Ingelheim, which is looking to bolster its cancer immunology portfolio. The assets acquired from Northern Biologics in the deal, announced Thursday, are designed to target two aspects of what’s known as the tumor microenvironment: stroma, or connective … Continue reading “Boehringer Ingelheim Acquires Northern Biologics’ Preclinical Pipeline”
Category: Europe
Genfit Contender in Heated NASH Drug Race Fails in Phase 3 Study
Genfit, once considered among the frontrunners in the biotech race to commercialize a treatment for nonalcoholic steatohepatitis (NASH), has come up short. The French company said Monday that its investigational treatment, elafibranor, did not meet the main goal of a late-stage trial evaluating its ability to resolve the fatty liver disease without worsening related scarring. … Continue reading “Genfit Contender in Heated NASH Drug Race Fails in Phase 3 Study”
Bio Roundup: Acquisitive Alexion, CRISPR on COVID, C. diff Success & More
Alexion Pharmaceuticals CEO Ludwig Hantson has made no secret that he wants to diversify his company’s drug portfolio and he has shown willingness to open the corporate checkbook to accomplish that goal. Last October, Alexion (NASDAQ: [[ticker:ALXN]]) struck a $930 million deal to acquire Achillion Pharmaceuticals, a biotech whose lead drug complements the Boston company’s … Continue reading “Bio Roundup: Acquisitive Alexion, CRISPR on COVID, C. diff Success & More”
AstraZeneca Diabetes Drug Gets FDA OK for Reducing Heart Health Risks
An AstraZeneca diabetes drug that brought in more than $1.5 billion in sales last year has won an FDA nod expanding its use to adults with systolic heart failure, a condition in which the heart struggles to pump with enough force to push enough blood into circulation. The drug, the once-daily pill dapagliflozin (Farxiga), was … Continue reading “AstraZeneca Diabetes Drug Gets FDA OK for Reducing Heart Health Risks”
Encouraging Signals for New Cancer Cell Therapy Strategies
Chimeric antigen receptor T-cell therapies have shown remarkable efficacy in leukemia and lymphoma patients who relapsed or were refractory to several prior treatments, but many challenges remain in the cancer cell therapy field. Strategies that may improve upon first-generation therapies were presented during the American Association for Cancer Research virtual meeting with encouraging early activity, … Continue reading “Encouraging Signals for New Cancer Cell Therapy Strategies”
Alexion Pharma Boosts Blood Drug Lineup With $1.4B Deal for Portola
Alexion Pharmaceuticals has agreed to buy Portola Pharmaceuticals in a $1.4 billion deal that brings it a first-in-class therapy for treating life-threatening bleeding. According to financial terms announced Tuesday, Boston-based Alexion (NASDAQ: [[ticker:ALXN]]) will pay $18 for each outstanding share of Portola (NASDAQ: [[ticker:PTLA]]). That price is a a nearly 132 percent premium to Monday’s … Continue reading “Alexion Pharma Boosts Blood Drug Lineup With $1.4B Deal for Portola”
Stemline Slated for Acquisition by Menarini in Deal Worth Up to $677M
Stemline Therapeutics, whose drug for a rare, aggressive type of acute leukemia was approved by the FDA about 18 months ago, has signed an acquisition deal with Italian biopharma Menarini Group. Stemline (NASDAQ: [[ticker:STML]]), a New York-based company, developed the first FDA-approved drug for blastic plasmacytoid dendritic cell neoplasm, or BPDCN. The drug, tagraxofusp (Elzonris) … Continue reading “Stemline Slated for Acquisition by Menarini in Deal Worth Up to $677M”
Pfizer Pays Valneva $130M for a Bite at a Lyme Disease Vaccine
If you’re looking for a Lyme disease vaccine, you can choose from among several—for your dog. A vaccine for humans hasn’t been available for years and few companies have tried to fill that void. Valneva has advanced its Lyme vaccine candidate to mid-stage clinical testing, and the company now has the help of drug giant … Continue reading “Pfizer Pays Valneva $130M for a Bite at a Lyme Disease Vaccine”
Bio Roundup: Remdesivir Data, Erasca’s $200M, a New FDA Nod & More
Remdesivir, the investigational Gilead Sciences antiviral drug, looks more likely than ever to become the first treatment authorized by the FDA to treat patients with COVID-19. National Institute of Allergy and Infectious Diseases (NIAID) head Anthony Fauci praised the drug after preliminary data released this week from a federally funded trial involving more than 1,000 … Continue reading “Bio Roundup: Remdesivir Data, Erasca’s $200M, a New FDA Nod & More”
ADC Therapeutics Resubmits IPO to Fuel Cancer Drug Filing, Launch Plans
Last fall, ADC Therapeutics (ADCT) concluded the time just wasn’t right for an IPO. Six months later, with its lead drug in a pivotal test and plans being drawn up for a regulatory submission and potential commercialization, the cancer drug developer has determined it needs cash now. ADCT refiled its IPO plans late Friday. The … Continue reading “ADC Therapeutics Resubmits IPO to Fuel Cancer Drug Filing, Launch Plans”
Bio Roundup: Fast FDA Approvals, Biogen Delays, ORIC’s IPO & More
COVID-19’s spread has clamped down on a lot of economic activity, including the work of developing and testing new medicines. But the FDA isn’t showing signs of slowing down, at least when it comes to drugs filed for accelerated approval. The regulator signed off on three such drugs in the past week. These approvals are … Continue reading “Bio Roundup: Fast FDA Approvals, Biogen Delays, ORIC’s IPO & More”
Why 2020 Is Pivotal for Microbiome Drug R&D (Or Maybe 2021, Given COVID-19)
The start of a potentially big biomedical breakthrough is blooming within all of us. Drug research aiming to turn bacteria into microbiome therapies now spans programs aiming to address gut disorders, autism, cancer, and more. Given the number of late-stage and mid-stage studies expected to report data in 2020—assuming they stay on track amid the … Continue reading “Why 2020 Is Pivotal for Microbiome Drug R&D (Or Maybe 2021, Given COVID-19)”
Cara Therapeutics Itching Drug Scratches Off Goals of Phase 3 Test
A Cara Therapeutics drug developed to treat the severe itching experienced by patients receiving hemodialysis has met the main goal of a second late-stage study, setting up the experimental medicine for regulatory filings in the US and Europe. Cara (NASDAQ: [[ticker:CARA]]) is testing its injectable drug, difelikefalin (Korsuva), in patients who have moderate-to-severe chronic kidney … Continue reading “Cara Therapeutics Itching Drug Scratches Off Goals of Phase 3 Test”
New COVID-19 Special Reports Explore Clinical Research During the Pandemic
Two new special reports on Xconomy Insight provide an expert view on how companies can sustain clinical trials during the COVID-19 crisis. “Decentralized Clinical Trials: The Call for a New Paradigm” and “Sustaining Clinical Research During the Crisis” offer the latest trends and technologies companies can use to keep business running as smooth as possible. … Continue reading “New COVID-19 Special Reports Explore Clinical Research During the Pandemic”
COVID-19 Vax Efforts Aim to Balance Speed, Efficacy in Race to Market
If Peter Marks had a magic wand to perfect the sophisticated process that takes a new vaccine from idea to reality, the US could have a way to prevent some people from COVID-19 infection in nine months to one year. In the real world, the journey to a vaccine OK’d under emergency guidelines is more … Continue reading “COVID-19 Vax Efforts Aim to Balance Speed, Efficacy in Race to Market”
Bio Roundup: Alnylam’s Billions, COVID-19 Vaccines, Moma Debuts & More
The public markets are moving erratically, but Alnylam Pharmaceuticals showed this week that selling equity isn’t the only way for biotech companies to raise cash. Late last year Alnylam (NASDAQ: [[ticker:ALNY]]) began exploring potential royalty deals for inclisiran, a drug that uses RNA interference to lower cholesterol. Alnylam had sold the drug’s development and commercialization … Continue reading “Bio Roundup: Alnylam’s Billions, COVID-19 Vaccines, Moma Debuts & More”
UroGen Gets FDA Nod for Low-Grade Upper Tract Urothelial Cancer Drug
The FDA on Wednesday approved a drug developed by UroGen Pharma to treat low-grade upper tract urothelial cancer, which rarely spreads but often recurs and can cause kidney damage in some patients. Urothelial cancer is the most common type of bladder cancer. Upper tract urothelial cancer (UCTC), however, affects the lining of the urinary system, … Continue reading “UroGen Gets FDA Nod for Low-Grade Upper Tract Urothelial Cancer Drug”
GSK and Sanofi Team Up on COVID-19 Vaccine, Aim for Clinic This Year
[Updated, 3:13 p.m. See below.] Pharmaceutical giants GlaxoSmithKline and Sanofi are teaming up on COVID-19 research, aiming to combine their respective technologies in a new vaccine that could start clinical trials in coming months. The full details of the agreement, which was announced Tuesday, are still being finalized. But the companies say the vaccine would … Continue reading “GSK and Sanofi Team Up on COVID-19 Vaccine, Aim for Clinic This Year”
More Trust, Collaboration in Pharma Needed to Reap Benefits of Data Science
Limited data isn’t an issue when it comes to how to best use computational tools to better prevent disease and treat patients—but how to more efficiently analyze existing information is. Industry veterans with experience in life sciences and data science floated their ideas about how the pharmaceutical industry could better plug in to the “big … Continue reading “More Trust, Collaboration in Pharma Needed to Reap Benefits of Data Science”
Blackstone Pays Alnylam $1B to Grab a Stake in RNAi Drug Inclisiran
Seven years ago Alnylam Pharmaceuticals sold rights to one of its preclinical drugs, gaining upfront cash and $180 million in potential milestone payments, plus royalties, for a therapy taking a novel approach to lowering cholesterol. On Monday, the company announced the sale of half of the royalties it’s owed to private equity firm Blackstone for … Continue reading “Blackstone Pays Alnylam $1B to Grab a Stake in RNAi Drug Inclisiran”
Biotech Roundup: GSK’s Ante, Shakeup at Sage, Telehealth’s Rise & More
The COVID-19 pandemic has stopped enrollment in many clinical trials and postponed the start of others but there is still life in the life sciences sector. The coronavirus research is expected. It’s the other activity that might come as a surprise. Two biotech companies have gone public in the past week; each upsized its offering and … Continue reading “Biotech Roundup: GSK’s Ante, Shakeup at Sage, Telehealth’s Rise & More”
Pfizer, BioNTech Say mRNA COVID-19 Vaccine Trials May Start This Month
Multiple COVID-19 vaccine candidates that use a new technology called messenger RNA are now being readied for clinical trials that Pfizer and BioNTech plan to start in coming weeks. The partnership pairs the mRNA vaccine technology of BioNTech (NASDAQ: [[ticker:BNTX]]) with the vaccine and clinical trial experience of Pfizer (NYSE: [[ticker:PFE]]). The companies said Thursday … Continue reading “Pfizer, BioNTech Say mRNA COVID-19 Vaccine Trials May Start This Month”
Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics
Some diseases have proven difficult to address using conventional tools of drug discovery that target disease-causing proteins. Roche is placing a $190 million bet on Arrakis Therapeutics, a startup whose technology aims for RNA—carriers of the genetic instructions that make these proteins in the first place. The cash, an upfront payment to Waltham, MA-based Arrakis, … Continue reading “Roche Pays $190M to Start RNA Drug Alliance With Arrakis Therapeutics”
Creating Consistent Value in Biotech Without Diluting Stakeholders
One of the greatest challenges for pre-commercial biotech companies is consistently generating capital necessary for operating costs and for R&D of new products that provide value to stakeholders, both for investors and patients. At OSE Immunotherapeutics we implemented a business model that allows us to be one of the rare French biotech companies without commercial … Continue reading “Creating Consistent Value in Biotech Without Diluting Stakeholders”
Polyneuron Adds Polyphor’s Debra Barker as Chief Medical Officer
Polyneuron Pharmaceuticals, a Swiss biotech that is developing a new class of biodegradable glycopolymers for the treatment of autoimmune diseases, has appointed Debra Barker as its chief medical officer. Most recently Barker was chief medical and development officer at Polyphor, which she left for personal reasons at the end of 2018. Her previous experience includes … Continue reading “Polyneuron Adds Polyphor’s Debra Barker as Chief Medical Officer”
GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months
GlaxoSmithKline has agreed to invest $250 million in infectious disease specialist Vir Biotechnology to launch a COVID-19 R&D alliance that the companies say could advance two experimental therapies to clinical testing this summer. The partnership will leverage antibody technology from Vir (NASDAQ: [[ticker:VIR]]) and genomics expertise from GSK (NYSE: [[ticker:GSK]]). The companies will work together … Continue reading “GSK, Vir Team Up in COVID-19 Pact Aiming to Reach the Clinic in Months”
Xconomy Releases Coronavirus Special Report on Containing the Pandemic Through Innovation & Investment
Based on the latest news and analysis, as well as conversations from industry experts during the Combatting Coronavirus live panel at BIO-Europe Spring®, Xconomy’s free special report delivers the latest COVID-19 news from the frontlines as top biotech and investment players offer their best plans and current progress in stemming and ultimately defeating the current … Continue reading “Xconomy Releases Coronavirus Special Report on Containing the Pandemic Through Innovation & Investment”
Dynacure Adds $55M As RNA-Targeted Muscle Disorder Drug Enters Clinic
Last month French biotech Dynacure dosed the first patient in an early-stage trial of its lead drug candidate, a treatment for a group of rare genetic muscle disorders. Now the company, which also has an office in Philadelphia, has landed a €50 million ($55 million) Series C financing round to move that investigational antisense medicine, … Continue reading “Dynacure Adds $55M As RNA-Targeted Muscle Disorder Drug Enters Clinic”
Bio Roundup: Biotech Billions, COVID-19 R&D, Zolgensma’s Path & More
The coronavirus pandemic has shaken the global economy, but three life sciences venture capital firms this week announced new funds totaling nearly $3 billion. ARCH Venture Partners led the pack, adding two funds totaling $1.46 billion to its war chest. Flagship Pioneering bagged $1.1 billion, and venBio Partners reeled in $394 million. Flagship CEO Noubar … Continue reading “Bio Roundup: Biotech Billions, COVID-19 R&D, Zolgensma’s Path & More”
Iteos Therapeutics Adds $125M to Advance Next-Gen Immunotherapies
Immunotherapies called checkpoint inhibitors have helped change the way a number of cancers are treated by blocking a tumor cell’s ability to hide from the immune system. Some patients don’t respond, however, or develop resistance to these drugs. Iteos Therapeutics has raised $125 million to advance new cancer treatments it is developing to target two … Continue reading “Iteos Therapeutics Adds $125M to Advance Next-Gen Immunotherapies”
Tapping Into the Innovation Grid: J&J, Data, and a Shifting Healthcare Focus
Johnson & Johnson’s global head of external innovation says there needs to be a shift in how healthcare research is funded to focus on early detection and curing rather than managing diseases. “When you look at the investment in research in the pharma industry, it’s all designed to treat established diseases,” William Hait, global head … Continue reading “Tapping Into the Innovation Grid: J&J, Data, and a Shifting Healthcare Focus”
Sanofi Adds mRNA COVID-19 Vaccine Bet Through Translate Bio Alliance
Sanofi is joining the array of companies pursuing a COVID-19 vaccine based on messenger RNA (mRNA), an experimental genetic technology intended to coax the body’s cells into producing proteins that treat a disease or spark immunity to one. Sanofi (NYSE: [[ticker:SNY]]) announced Friday that it will develop COVID-19 vaccine candidates with Translate Bio (NASDAQ: [[ticker:TBIO]]), … Continue reading “Sanofi Adds mRNA COVID-19 Vaccine Bet Through Translate Bio Alliance”
Bio Roundup: Clinical Trials Paused, New MS Drug, Kallyope’s Cash & More
Finding and enrolling patients for clinical trials is always challenging. The coronavirus pandemic has made it nearly impossible. Fallout from the spread of COVID-19 infections led several companies to declare this week that they would stop enrolling patients in clinical trials or postpone studies that have not yet started. Eli Lilly (NYSE: [[ticker:LLY]]) said that … Continue reading “Bio Roundup: Clinical Trials Paused, New MS Drug, Kallyope’s Cash & More”
Oncology Needs Combo Therapies & More Data Analysis, Says Bio-Europe Spring Panel
Future improvements in cancer care are most likely to stem from combinations therapies and data-driven prevention efforts, as well as breakthrough drugs. That’s the message life sciences experts shared this week during a webcast on the topic of “oncology’s next decade” recorded for the BIO-Europe Spring partnering conference. The event is produced by EBD Group, … Continue reading “Oncology Needs Combo Therapies & More Data Analysis, Says Bio-Europe Spring Panel”
AstraZeneca Joins RNAi Mix, Pledging $80M to Silence Therapeutics
After years of research, technology for silencing a gene—stopping it from producing a disease-causing protein—has reached patients. AstraZeneca is now angling for a position in this burgeoning field through an alliance with Silence Therapeutics, a biotech developing such gene-silencing drugs. According to deal terms announced Wednesday, AstraZeneca (NYSE: [[ticker:AZN]]) will pay London-based Silence (LON: [[ticker:SLN]]) … Continue reading “AstraZeneca Joins RNAi Mix, Pledging $80M to Silence Therapeutics”
Palforzia Peanut Allergy Immunotherapy: Aimmune CEO on REMS, Manufacturing
Aimmune Therapeutics Inc. is navigating a host of new challenges as it launches Palforzia, the first peanut allergy immunotherapy to be approved by the US Food and Drug Administration. Most notably, it must get physician practices and individual allergists certified to administer the treatment. Aimmune (NASDAQ: AIMT) president and CEO Jayson Dallas talked to our sister … Continue reading “Palforzia Peanut Allergy Immunotherapy: Aimmune CEO on REMS, Manufacturing”
Investors Shaken by Coronavirus Sow Seeds of M&A, Financing Slowdown
The coronavirus pandemic is narrowing the avenues open to biotechs for financing their endeavors, according to some industry veterans. “I think that fear of losing out has pretty much gone out the window right now,” said Equillium (NASDAQ: [[ticker:EQ]]) CEO Bruce Steel in a phone interview with Xconomy, speaking generally of investor appetite. “I think … Continue reading “Investors Shaken by Coronavirus Sow Seeds of M&A, Financing Slowdown”
FDA Rejects Boehringer Ingelheim, Eli Lilly Drug for Type 1 Diabetes
A type 2 diabetes drug marketed by Boehringer Ingelheim and Eli Lilly has fallen short of a bid to expand the medicine’s approval to patients who have type 1 diabetes. The FDA on Friday rejected the application for the drug, empagliflozin (Jardiance), for use in addition to insulin as a treatment for type 1 diabetes … Continue reading “FDA Rejects Boehringer Ingelheim, Eli Lilly Drug for Type 1 Diabetes”
Bio Roundup: Coronavirus Diagnostics, Therapeutics, Vaccines & More
The past week brought a sea change in many of our daily lives as the impact of the continued spread of the novel coronavirus altered how we work and play as communities around the world attempt to slow its spread. Xconomy, as always, is focused on the stories coming out of the life sciences community. … Continue reading “Bio Roundup: Coronavirus Diagnostics, Therapeutics, Vaccines & More”
Qiagen Juices RNA Extraction Kit Capacity to Feed Coronavirus Test Needs
Dutch molecular diagnostics company Qiagen said Tuesday it would “dramatically” ramp up production of the components needed for the RNA extraction kits used to detect the novel coronavirus in a patient sample. Isolating genetic material from a biological sample is a key step in the testing process, which has not been widespread in the US … Continue reading “Qiagen Juices RNA Extraction Kit Capacity to Feed Coronavirus Test Needs”
Novo Nordisk Pauses 3 Clinical Trials Testing Hemophilia Therapy
On Monday Danish company Novo Nordisk announced it would stop treating patients enrolled in clinical trials evaluating an investigational hemophilia drug it developed after three of those receiving the drug reported “thrombotic events.” Hemophilia, an inherited blood disorder, is characterized by low levels of proteins called clotting factors, which help patients’ blood to clot appropriately. … Continue reading “Novo Nordisk Pauses 3 Clinical Trials Testing Hemophilia Therapy”
Bio Roundup: Pandemic Declared, Rubius Restarts, Kymera’s Cash & More
The financial markets are tumbling, event cancellations are mounting, and sports leagues are suspending their seasons. March Madness is in full swing but not in any way that people wanted or expected. The World Health Organization this week declared that the COVID-19 outbreak was serious enough to classify as pandemic. The toll on public health … Continue reading “Bio Roundup: Pandemic Declared, Rubius Restarts, Kymera’s Cash & More”
CureVac Founder Ingmar Hoerr to Replace CEO Dan Menichella
German biotech CureVac, a developer of messenger RNA-based drugs, said company founder Ingmar Hoerr would take over for CEO Dan Menichella. Menichella joined the company in 2017 to run its US operations, which are in Boston. He took over the CEO role from Hoerr in 2018. In its statement announcing the transition, CureVac credited Menichella … Continue reading “CureVac Founder Ingmar Hoerr to Replace CEO Dan Menichella”
Harbour BioMed Tacks on $75M to Advance Broad Biologics Pipeline
A biotech born out of an antibody platform company has added another $75 million to its investment haul, money it says will allow it to advance its clinical-stage compounds and continue to build its portfolio of earlier-stage therapeutics. Shanghai-based Harbour BioMed emerged in 2016 after acquiring technology developed by Harbour Antibodies, a Dutch company that … Continue reading “Harbour BioMed Tacks on $75M to Advance Broad Biologics Pipeline”
Kymera Closes $102M Round to Bring Protein-Busting Drugs to the Clinic
Reuse and recycle is more than an environmental slogan. It’s also a succinct description of how cells deal with old or damaged proteins. Kymera Therapeutics is developing drugs that use this cyclical cellular process to treat disease, and it has raised $102 million to move into clinical testing next year. The Series C round of … Continue reading “Kymera Closes $102M Round to Bring Protein-Busting Drugs to the Clinic”
With Bristol and Otsuka on Board, LSP Raises $620M EU Life Sciences Fund
Healthcare investment firm LSP has raised what it says is the largest ever European fund focused on life sciences ventures. The Amsterdam, Netherlands-headquartered firm aimed to bring in $450 million in the final fundraiser for its LSP 6 life science private equity fund but has ended up with $620 million (€550 million) to invest in … Continue reading “With Bristol and Otsuka on Board, LSP Raises $620M EU Life Sciences Fund”
Cushing’s Disease Drug That Novartis Sold to Recordati Nabs FDA Nod
A Cushing’s disease drug whose rights Novartis sold to Italy-based Recordati last year now has FDA approval. Cushing’s disease is a rare disorder in which the adrenal glands make too much of a hormone called cortisol. The Novartis (NYSE: [[ticker:NVS]]) drug, osilodrostat (Isturisa), is intended to block an enzyme key to cortisol production. The FDA … Continue reading “Cushing’s Disease Drug That Novartis Sold to Recordati Nabs FDA Nod”
Bio Roundup: Gilead’s $4.9B Deal, COVID-19 Collabs, IPO Plans & More
Last month, Gilead Sciences CEO Daniel O’Day announced plans to introduce 10 “transformative medicines” over the next 10 years. Acquisitions would help meet that ambitious goal, and this week Gilead announced one of them: a nearly $5 billion deal for cancer immunotherapy developer Forty Seven. Forty Seven’s lead CD47-blocking drug—the company is named after the … Continue reading “Bio Roundup: Gilead’s $4.9B Deal, COVID-19 Collabs, IPO Plans & More”
PsiOxus Therapeutics Appoints Tom Lillie as Chief Medical Officer
Gene therapy developer PsiOxus Therapeutics on Thursday announced it has appointed Tom Lillie as its chief medical officer. Lillie previously held senior oncology roles at Amgen (NASDAQ: [[ticker:AMGN]]) and MSD (NYSE: [[ticker:MRK]]) (as Merck is known outside of the US and Canada). The Oxford, England-based company also said it moved its third gene therapy for … Continue reading “PsiOxus Therapeutics Appoints Tom Lillie as Chief Medical Officer”
Sanofi Wins FDA Nod for Combo Therapy in Multiple Myeloma
The FDA on Monday approved a Sanofi antibody drug for adults with multiple myeloma whose disease hasn’t responded to at least two prior therapies, including the chemotherapy lenalidomide and a proteasome inhibitor. The drug, isatuximab-irfc (Sarclisa), was OK’d for patients in combination with pomalidomide, a chemotherapy, and dexamethasone, a corticosteroid (pom-dex). The Sanofi (NYSE: [[ticker:SNY]]) … Continue reading “Sanofi Wins FDA Nod for Combo Therapy in Multiple Myeloma”