Managing Design: Talking with Jim Heppelmann, Parametric Technology’s Incoming CEO

Parametric Technology Corporation, better known as PTC (NASDAQ: [[ticker:PMTC]]), is one of the leading companies in Boston’s “3D design cluster”—the group of companies focusing on computer-aided design (CAD) software for the construction, engineering, architecture, and manufacturing sectors. Back in May, Needham, MA-based PTC announced that its current president and CEO, Dick Harrison, will become the … Continue reading “Managing Design: Talking with Jim Heppelmann, Parametric Technology’s Incoming CEO”

CEO Eric Meier Out at Calypso Medical; Layoffs Reported

At least three people were laid off from Seattle-based Calypso Medical Technologies on Wednesday, and former CEO Eric Meier has left the firm, according to a source close to the company. Director of marketing David Gusdorf declined to comment on the layoffs. A request for comment from Eric Meier was not immediately answered. Vice president … Continue reading “CEO Eric Meier Out at Calypso Medical; Layoffs Reported”

Cypress Bio Rejects Buyout Offer, Shutting Down Commercial Business

Here’s one solution to a suitor’s unsolicited buyout offer: Make yourself ugly, at least to that suitor. San Diego’s Cypress Bioscience (NASDAQ: [[ticker:CYPB]]) got a $160 million cash buyout offer last month from Ramius Value and Opportunity Advisors, part of the New York-based, $7.8-billion Ramius hedge fund group. Ramius, which had accumulated a 10 percent … Continue reading “Cypress Bio Rejects Buyout Offer, Shutting Down Commercial Business”

Why Micro-VCs Are So Damn Friendly, and More Insights from Rob Go’s and David Beisel’s Blogs

Some quick observations on the micro VC phenomenon, spurred by running into Rob Go this morning at the Andala Café in Central Square…Go is the co-founder of NextView Ventures, a seed-stage tech investment firm (previously he was with Spark Capital). “Micro VC” refers to the emerging segment of venture capital in which investors put small … Continue reading “Why Micro-VCs Are So Damn Friendly, and More Insights from Rob Go’s and David Beisel’s Blogs”

ThredUP Swaps Boston-Area Office for San Francisco; Leaving New England Has Tradeoffs, CEO Says

News hit yesterday that Cambridge, MA-based thredUP, an online platform for swapping used children’s clothing, will be packing up for San Francisco next month, as first reported on Scott Kirsner’s Innovation Economy blog. The company has signed a lease for a building near the city’s Union Square neighborhood starting in September, CEO James Reinhart says. … Continue reading “ThredUP Swaps Boston-Area Office for San Francisco; Leaving New England Has Tradeoffs, CEO Says”

How to Banish Business Cards: A Ranked List of Digital Options

Business cards are the scourge of anyone trying to go paperless. Sure, the basic concept is brilliant: a business card provides a compact, easily transferable storage location for all of the key data about another person. But it’s a mystery to me why the traditional paper business card, a descendant of the 17th-century visiting card, … Continue reading “How to Banish Business Cards: A Ranked List of Digital Options”

Genentech Inks Antibody Deal, Cytokinetics Sticks With Science First, BioMarin Scraps Drug, & More Bay Area Life Sciences News

A lot of the Bay Area news this week sent ripple effects up and down the West Coast, to our other Xconomy network cities of Seattle and San Diego. —Genentech, the U.S.-based unit of Roche, expanded an alliance with Seattle Genetics (NASDAQ: [[ticker:SGEN]]) to develop “empowered antibodies” against cancer. Genentech is paying $12 million upfront, … Continue reading “Genentech Inks Antibody Deal, Cytokinetics Sticks With Science First, BioMarin Scraps Drug, & More Bay Area Life Sciences News”

Venture-Backed IPOs Recovering but Weak: We Compare Results for San Francisco, Boston, Seattle, & San Diego

Amid an overall improvement in IPOs, a survey by Menlo Park, CA-based VentureDeal shows 21 venture-capital backed technology or life sciences companies went public in the U.S. during the first six months of 2010, raising a total of $1.9 billion in gross proceeds. VentureDeal’s IPO activity report is focused on a specific subgroup of technology … Continue reading “Venture-Backed IPOs Recovering but Weak: We Compare Results for San Francisco, Boston, Seattle, & San Diego”

How Lilly Let Telaprevir Go to Vertex, SV Focusing on Health IT With Latest Fund, Genzyme Isis Cholesterol Drug Shows Strong in Clinical Trial, & More Boston-Area Life Sciences News

The past week brought news of clinical trials and funding from drugmakers, as well as a look at venture investing strategy in health IT, and an update on the Genzyme-Sanofi buyout rumors. Catch up on those stories and more below: —With its recently closed $523 million fund, SV Life Sciences plans to put a greater … Continue reading “How Lilly Let Telaprevir Go to Vertex, SV Focusing on Health IT With Latest Fund, Genzyme Isis Cholesterol Drug Shows Strong in Clinical Trial, & More Boston-Area Life Sciences News”

Korrio Raises $3.3M, Enters Youth Sports Automation Sector

Mercer Island, WA-based Korrio (formerly known as iPlaySportz) has raised $3.3 million in equity, according to a regulatory filing. The company is run by Steve Goldman, formerly the CEO of Isilon Systems and a senior executive at F5 Networks, and Brad Hefta-Gaub, of Sweat365.com, Revenue Science, and Real Networks, according to a preliminary version of … Continue reading “Korrio Raises $3.3M, Enters Youth Sports Automation Sector”

How Do You Spell Innovation? H-O-R-S-E. Tourney in Kendall Square Tomorrow

Calling all basketball players and fans… Want to hang out and shoot some hoops on a summer afternoon? We at Xconomy—OK, at least Bob and I—are excited to invite our readers and members of the startup and innovation community to an informal H-O-R-S-E tourney tomorrow. Come one, come all. It will take place from 1:00-2:30 … Continue reading “How Do You Spell Innovation? H-O-R-S-E. Tourney in Kendall Square Tomorrow”

Viridity Raises $8M More, Looks to Make Data Centers More Energy Efficient by Tracking Each IT Component

Remember last year when there was that flap about how much power it takes, and how much carbon is emitted, when you do a Google search? OK, so maybe you can do something like 15,000 searches before you reach the environmental footprint of a cheeseburger. But there are still a slew of companies tackling the … Continue reading “Viridity Raises $8M More, Looks to Make Data Centers More Energy Efficient by Tracking Each IT Component”

With Quizzle’s Move Downtown, Dan Gilbert Declares Detroit Area ‘WEBward Avenue’ for Tech Revitalization

Dan Gilbert, the chairman and founder of Quicken Loans, is hoping that if he declares Woodward Avenue, Detroit’s main drag, to be a new, tech-centered “WEBward Avenue” often enough, it just might come true. It also doesn’t hurt that he has the money and clout to perhaps make it a self-fulfilling prophecy. That’s why the … Continue reading “With Quizzle’s Move Downtown, Dan Gilbert Declares Detroit Area ‘WEBward Avenue’ for Tech Revitalization”

Of Genzyme, Sanofi-Aventis, Biotech Buyout Gossip, and Angry Patients

Genzyme (NASDAQ:[[ticker:GENZ]]) and Sanofi-Aventis (NYSE:[[ticker:SNY]]) have continued to be tight-lipped about their rumored buyout talks, making no official comments about Paris-based Sanofi’s reported efforts to scoop up the largest biotech company in Massachusetts. But the two companies’ silence hasn’t kept unnamed insiders from whispering updates on the Genzyme-Sanofi talks into the eager ears of the … Continue reading “Of Genzyme, Sanofi-Aventis, Biotech Buyout Gossip, and Angry Patients”

Conatus Gets Idun, Trius Goes Public, BrainCells Gets Sabcomeline, & More San Diego-Area Life Sciences News

Either I have too much time on my hands, or the first half of today’s headline is pretty close to a Haiku in English. Don’t grade me. Let’s just move on with the roundup of life sciences news. —We briefly noted that San Diego’s Conatus Pharmaceuticals acquired Idun Pharmaceuticals for an undisclosed sum from Pfizer, … Continue reading “Conatus Gets Idun, Trius Goes Public, BrainCells Gets Sabcomeline, & More San Diego-Area Life Sciences News”

Money for the Middle Stage: Part 2 of a Conversation with Scale Venture Partners

I sat down last week with Kate Mitchell and Rory O’Driscoll, both general partners at mid-stage venture firm Scale Venture Partners in Foster City, CA. The firm was interesting to me because it lives up to the name: The folks at Scale don’t invest in early-stage startups, where the nature of the product is often … Continue reading “Money for the Middle Stage: Part 2 of a Conversation with Scale Venture Partners”

Gilead’s Lung Drug Ace, Bruce Montgomery, Hits Free Agent Market, Scopes Startup Ideas

Bruce Montgomery, the prolific drug developer and a leader of Seattle’s biotech cluster, has become a free agent, Xconomy has learned. Montgomery, 57, has told colleagues at Gilead Sciences that he is resigning from his full-time operating job as senior vice president of Gilead’s respiratory drug division in Seattle. He plans to continue working for … Continue reading “Gilead’s Lung Drug Ace, Bruce Montgomery, Hits Free Agent Market, Scopes Startup Ideas”

EnergySavvy Carves Out Cleantech Space, Focuses on Making Energy Retrofitting Easy

[Updated: 4:40pm Pacific] It’s somewhat surprising to me how long the cleantech industry—no matter how innovative—has been somewhat eclipsed by other up-and-coming tech sectors. In the ’90s the tech industry was dominated by the software and dotcom bubble. In the 2000s, the rising stars were wireless and mobile. Today, it’s cloud computing and social media. … Continue reading “EnergySavvy Carves Out Cleantech Space, Focuses on Making Energy Retrofitting Easy”

Advanced Electron Beams, With DOE and VC Money in Tow, Tackles Air Pollution

Wilmington, MA-based Advanced Electron Beams is developing energy-efficient technology in a sector that typically doesn’t attract the same attention as hybrid cars or green buildings: industrial manufacturing. The company makes a device that CEO Mitch Tyson describes as a stainless-steel light bulb, which emits a cloud of high-speed electrons to produce a blue glow, replacing … Continue reading “Advanced Electron Beams, With DOE and VC Money in Tow, Tackles Air Pollution”

Dendreon Shows Provenge Demand, Seattle Genetics Inks Big Deal, Corey Gets Top Hutch Job, & More Seattle-Area Life Sciences News

The biotech world has been dying to know how Dendreon is doing with the market introduction of its groundbreaking prostate cancer drug, and this week we found out. —Dendreon (NASDAQ: [[ticker:DNDN]]) had a big week in the news. Investors were eagerly awaiting the first quarterly report from the Seattle biotech company reflecting actual product sales … Continue reading “Dendreon Shows Provenge Demand, Seattle Genetics Inks Big Deal, Corey Gets Top Hutch Job, & More Seattle-Area Life Sciences News”

In-Q-Tel, the CIA’s Investment Arm, Quietly Backing Seventh Sense Biosystems

Few people know that In-Q-Tel, the nonprofit investment arm of the U.S. intelligence community, has a stake in the Cambridge, MA-based startup Seventh Sense Biosystems. Neither In-Q-Tel nor Seventh Sense has ever publicized their relationship, which came to Xconomy’s attention recently. Arlington, VA-based In-Q-Tel—which invests in lots of startups with technologies that could aid the … Continue reading “In-Q-Tel, the CIA’s Investment Arm, Quietly Backing Seventh Sense Biosystems”

St. Bernard Buys Red Condor Assets

San Diego’s St. Bernard Software, which provides the iPrism network security appliance, said today it has acquired the e-mail security technology and substantially all other assets of Red Condor, a six-year-old startup near Sonoma State University. St. Bernard (OTCBB: [[ticker:SBSW]]) says the acquisition of Red Condor’s spam-and-bot filtering technology enhances and expands its security offering, … Continue reading “St. Bernard Buys Red Condor Assets”

The Story Behind Rick Snyder: Seasoned Tech Entrepreneur Wins Michigan GOP Primary

It’s near the beginning of 2001 and I walk into the Ann Arbor, MI, offices of Ardesta for the first time. I am introduced to Rick Snyder, CEO of the business accelerator. After we exchange our greetings and I’m shown my new desk, a colleague tells me that Snyder will run for governor of Michigan … Continue reading “The Story Behind Rick Snyder: Seasoned Tech Entrepreneur Wins Michigan GOP Primary”

Genzyme, Isis Cholesterol Drug Passes Pair of Clinical Trials; Shares Fall Anyway

Genzyme has been all over the news in the past week because of takeover speculation, but today when fundamental news came out about one of its most important assets for the future, investors yawned. Cambridge, MA-based Genzyme (NASDAQ: [[ticker:GENZ]]) and its partner, Carlsbad, CA-based Isis Pharmaceuticals (NASDAQ: [[ticker:ISIS]]) said today that their drug for people … Continue reading “Genzyme, Isis Cholesterol Drug Passes Pair of Clinical Trials; Shares Fall Anyway”

San Diego Takes Center Stage as Ecotality Works Ahead of Electric Vehicle Rollouts

San Diego utility executives and transportation planners, together with Ecotality CEO Jonathan Read, yesterday unveiled a blueprint for deploying electric vehicle charging stations throughout the region—making San Diego the beginning point for a new era of rechargeable transportation. “It’s a milestone on the road to the mass-marketing of electric cars,” decreed Ron Roberts, a San … Continue reading “San Diego Takes Center Stage as Ecotality Works Ahead of Electric Vehicle Rollouts”

Stealthy Beaumaris Networks Banks $9M, Appears to Be Expanding in China

Beaumaris Networks, a surreptitious startup developing technology for video service providers, has raised just shy of $9 million in a planned $10 million funding round, according to an SEC filing. The Boxborough, MA-based firm, which was launched in February 2009, also says on its website that it has a research and development operation in Beijing. … Continue reading “Stealthy Beaumaris Networks Banks $9M, Appears to Be Expanding in China”

Making Customer Support Sexy: Zendesk’s Help Desk Lovefest

If it weren’t for unhappy customers, San Francisco’s Zendesk wouldn’t be in business. After all, the company makes Web-based help desk software that’s used by thousands of companies to track, and ideally resolve, complaints submitted by their users. But Zendesk probably didn’t think that a plan to impose steep price increases, announced more than two … Continue reading “Making Customer Support Sexy: Zendesk’s Help Desk Lovefest”

Skyhook Wireless Digs In, Touts Location Patents After Apple Drops Technology From iPhone

When it comes to mobile software and devices these days, it’s all about location, location, location. And if you’re a small, leading-edge company in the sector—if you’ve played a pioneering role in bringing location-based technologies to market, and millions of devices use your software—well, you’d better watch your back. That’s my take upon hearing the … Continue reading “Skyhook Wireless Digs In, Touts Location Patents After Apple Drops Technology From iPhone”

Zulily, Off to Fast Start in Private Sale E-Commerce, Raises $6M More from August Capital, Maveron

Seattle-based private-sales company Zulily is announcing today it has closed $6 million in Series B financing led by August Capital, along with existing investor Seattle-based Maveron. The website, which went live on January 27, rolled out of stealth back in December with the support of an initial $4.6 million round. Six short months later, co-founder … Continue reading “Zulily, Off to Fast Start in Private Sale E-Commerce, Raises $6M More from August Capital, Maveron”

Cytokinetics, Defying the Fashion in Biotech, Sticks with Gradual Science-Based Strategy

Cytokinetics isn’t trying to do the most popular thing at the moment. The company is taking time to do a lot of basic science and methodical clinical trials to do the best it can to make sure it has something that works. That’s not exactly the most fashionable thing in today’s high-speed investing environment, when … Continue reading “Cytokinetics, Defying the Fashion in Biotech, Sticks with Gradual Science-Based Strategy”

How Eli Lilly Let a Billion-Dollar Molecule Slip Away and Make a Fortune for Vertex

Careers can be made in the drug development business on a single drug like telaprevir, the hepatitis C treatment from Vertex Pharmaceuticals (NASDAQ:[[ticker:VRTX]]). If it gets approved, the drug has the potential to become a leading treatment for the chronic liver disease—and to make a multibillion-dollar fortune for Cambridge, MA-based Vertex—within the next few years. … Continue reading “How Eli Lilly Let a Billion-Dollar Molecule Slip Away and Make a Fortune for Vertex”

Boston-Power Expands Series E Round, Storwize Scooped Up By IBM, PerkinElmer Acquires VisEn, & More Boston-Area Deals News

In the last week, we’ve seen acquisitions in both the life sciences and IT spaces, as well as an IPO and startup funding. —Curt Schilling’s Maynard, MA-based video game company, 38 Studios, attracted $75 million in loan guarantees from the Rhode Island Economic Development Corporation, according to media reports. In exchange, the company has pledged … Continue reading “Boston-Power Expands Series E Round, Storwize Scooped Up By IBM, PerkinElmer Acquires VisEn, & More Boston-Area Deals News”

Dendreon Conference Call Notebook: The Tale of a Provenge Launch Ramp-Up

Dendreon’s drug isn’t as simple as a pill in a bottle, and neither is telling the story about how it performs in the marketplace. But the Seattle-based biotech company offered a lot of information in a conference call today about how its groundbreaking prostate cancer drug is performing in its first few months on the … Continue reading “Dendreon Conference Call Notebook: The Tale of a Provenge Launch Ramp-Up”

Tech Coast Angels Forms New Fund to Make Collective Startup Investments

Southern California’s Tech Coast Angels (TCA) says today it is forming a new fund that will allow non-members to collectively participate in startup investments, a move that should add some firepower to TCA deals and could smooth out the funding process for entrepreneurs. The formation of the Angel Capital Entrepreneurial Fund (ACE Fund) comes at … Continue reading “Tech Coast Angels Forms New Fund to Make Collective Startup Investments”

Dendreon Misses Wall Street’s (Already Low) Expectations for Provenge Sales

Dendreon, in its first two months on the market, sold a lot less of its groundbreaking drug for prostate cancer than analysts were expecting. The Seattle-based biotech company (NASDAQ: [[ticker:DNDN]]) said it generated $2.81 million in sales of its first FDA-approved product, sipuleucel-T (Provenge) for prostate cancer. That’s less than the $4.4 million average estimate … Continue reading “Dendreon Misses Wall Street’s (Already Low) Expectations for Provenge Sales”

Appswell Powers iPhone App for GE Ecomagination Challenge in Cleantech

Cambridge, MA-based Appswell’s crowdsourced approach to mobile applications development is going green. The startup announced today it is powering the mobile app component for General Electric’s Ecomagination Challenge, a $200 million contest aimed at generating innovative ideas in renewable energy, smart grid technology, and eco-friendly building technology. Appswell, which describes itself as an “American Idol” … Continue reading “Appswell Powers iPhone App for GE Ecomagination Challenge in Cleantech”

Most Automotive Infotainment Systems Will Run On Open-Source Genivi By 2015, Report Says

If you’re thinking about developing an app for use in automobiles, you might want to take a look at a new report released by the Genivi Alliance. The coalition of auto companies, suppliers, silicon providers, and software companies predicts its own open-source Genivi operating system will be running most in-vehicle infotainment systems by 2017.  Genivi, … Continue reading “Most Automotive Infotainment Systems Will Run On Open-Source Genivi By 2015, Report Says”

SilverRail, $9M in Tow, Goes After International Railway Market in Online Travel

It’s about time someone cracked the online travel search-and-ticketing market for trains. Hotels and airlines are pretty crowded sectors, especially in the U.S., but railway systems might hold some promise—at least abroad. Enter SilverRail Technologies, a young company based in the Boston and London areas. Founded a year ago by CEO Aaron Gowell, formerly of … Continue reading “SilverRail, $9M in Tow, Goes After International Railway Market in Online Travel”

You’re Invited to an Open House Celebrating Xconomy’s Arrival in San Francisco

We may be little bit behind schedule with this, given that we launched Xconomy San Francisco on June 14, but hey, it’s never too late to throw a party. All of our new friends and fans in the Bay Area are cordially invited to an August 13 open house at Xconomy’s new San Francisco headquarters—which … Continue reading “You’re Invited to an Open House Celebrating Xconomy’s Arrival in San Francisco”

Genentech Agrees to Pay Seattle Genetics Up to $900M for “Empowered Antibodies”

Genentech and Seattle Genetics have been working together for eight years on how to make antibody drugs that can really firebomb cancer cells, and today they are raising the ante in a big way. Seattle Genetics (NASDAQ: [[ticker:SGEN]]) said today that Genentech, the U.S.-based unit of Roche, has agreed to pay $12 million in upfront … Continue reading “Genentech Agrees to Pay Seattle Genetics Up to $900M for “Empowered Antibodies””

Seattle’s Growing Advantage in The Cloud

Cloud computing and biotech are the two most important nonlinearly-growing economic sectors. These two sectors intersect in Seattle in a unique way that has important implications for all involved. Small changes now will make big changes in what our lives are like decades from today, and Seattleites will have a ringside seat. For now, there … Continue reading “Seattle’s Growing Advantage in The Cloud”

Lessons for Budding Angel Investors from Y Combinator’s AngelConf: Part 2

On Monday I published the first part of a double-header post excerpting the most interesting talks from last week’s AngelConf event at Y Combinator in Mountain View, CA. Attended by some 120 nascent angel investors—very few of whom looked more than 35 years old—the conference was designed to give a group of experienced angel investors … Continue reading “Lessons for Budding Angel Investors from Y Combinator’s AngelConf: Part 2”

Who Are You? Charting the Demographics of Venture-Backed Internet Startups

Our friends at CB Insights, a New York information services firm that tracks investments in private companies, have been busy gathering new insights about the demographics of venture-backed Internet companies. They’ve put together a report based on data about the founders of 165 early stage Internet companies that raised their first round of institutional venture … Continue reading “Who Are You? Charting the Demographics of Venture-Backed Internet Startups”

Ascent Venture Partners Says Data Intelligence Is the Next Big Thing, Tech Startups Will Get Scooped Up Like Biotechs, and Bigger Isn’t Always Better

Boston-based Ascent Venture Partners seems to know what it’s good at. The firm, which started as a VC subsidiary of the Pioneer Group and went independent in 1999, has stayed faithful to its focus on early-stage IT companies. “We don’t try to redefine ourselves around every fund on what’s the flavor of the day,” Ascent … Continue reading “Ascent Venture Partners Says Data Intelligence Is the Next Big Thing, Tech Startups Will Get Scooped Up Like Biotechs, and Bigger Isn’t Always Better”

Dendreon Watchers: Buckle Up for Action in First Quarterly Report With Actual Sales

Dendreon followers, it’s time to get ready for another spin on the great NASDAQ merry-go-round later today. The Seattle-based biotech firm (NASDAQ: [[ticker:DNDN]]), a poster child for wild and sometimes irrational stock market swings, is preparing to release its first quarterly report this afternoon as a company with actual sales from a product. Whatever Dendreon … Continue reading “Dendreon Watchers: Buckle Up for Action in First Quarterly Report With Actual Sales”

Daptiv Acquired, DocuSign Inks Partnership, Healthcare and Energy Companies Bring in the Most Dough, & More Seattle-Area Deals News

It’s been a relatively slow week for Seattle-area technology deals (sunny weather strikes again!). Only one local tech startup reported financing over this last week, while, much like the week before, two others were acquired, this time both by big companies down south.. Take a look at this week’s highlights: —Seattle-based project management software developer … Continue reading “Daptiv Acquired, DocuSign Inks Partnership, Healthcare and Energy Companies Bring in the Most Dough, & More Seattle-Area Deals News”

The Embargo System in Science News Needs Some Peer Review

Ever wonder how it is that the day a big scientific paper is published, or a groundbreaking presentation is given at a meeting, all major media outlets seem to have the story right away? It doesn’t happen by chance. The massive coordination effort is known as the embargo system. It is one of the most … Continue reading “The Embargo System in Science News Needs Some Peer Review”

Lessons for Budding Angel Investors from Y Combinator’s AngelConf: Part 1

You’ve been a part of the startup world for a while, and you’ve had a successful exit or two. You have some money laying around that you don’t know what to do with. You feel a vague sense of owing something back to the technology community, and you want to keep a hand in the … Continue reading “Lessons for Budding Angel Investors from Y Combinator’s AngelConf: Part 1”

Delve Networks Acquired By Limelight

Delve Networks, the Seattle-based online video hosting and “search inside” video technology startup, said today it has been acquired by Tempe, AZ-based Limelight Networks (NASDAQ: [[ticker:LLNW]]). Though financial terms of the deal were not disclosed, blogger Dan Rayburn, at Businessofvideo.com, reported the deal valued Delve at about $10 million. Delve, founded in 2006 (then known … Continue reading “Delve Networks Acquired By Limelight”