San Diego’s Cadence Gets a Generic Headache, aTyr Pharma Seeks Structure for Diverse Funding, CareFusion Plans Global Expansion, & More San Diego Life Sciences News

Buying, Selling, Agreeing. San Diego’s life sciences companies conducted a lot of different transactions over the past week. We have a rundown for you.

—San Diego’s ResMed, which specializes in medical devices used to treat sleep apnea and related breathing disorders, said it acquired BiancaMed, a private Irish maker of sensor technology used to monitor sleep and breathing. Financial terms were not disclosed, but a ResMed spokeswoman told the U-T the deal represented a significant premium over the $15.8 million that all of BiancaMed’s investors—include ResMed—previously put into the company.

—-The executive chairman of San Diego’s aTyr Pharma, John Mendlein provided an overview of an idea he conceived that would enable nonprofit disease foundations to help fund aTyr’s R&D, along with big government agencies and privately held pharmaceutical and biotech companies.

ActivX business development executive Robert Hillman alerted me yesterday to just-published findings, which the San Diego-based unit of Japan’s Kyorin Pharmaceutical said validate its KiNatiV technology. Hillman says the technology uses probes that interact and bind with kinases within cells of any tissue from any species, enabling ActivX to use sophisticated mass spectroscopy to identify key attributes of kinases that can’t be obtained any other way. In a statement, the company says, “Given the utility of kinase inhibitors as research tools and promising agents for molecular-targeted therapy, the opportunity to characterize their interactions with native endogenous kinases undoubtedly represents a significant step forward.”

—San Diego’s Cadence Pharmaceuticals (NASDAQ: [[ticker:CADX]]) got a new headache, after the FDA disclosed that an unidentified competitor wants to bring a generic version of Cadence’s pain reliever to market in the United States. The FDA allowed Cadence to start selling its injectable formulation of acetaminophen to hospitals just nine months ago.

Life Technologies (NASDAQ: [[ticker:LIFE]]), the Carlsbad CA-based giant in biomedical diagnostics, settled an intellectual property dispute with Fluidigm (NASDAQ: [[ticker:FLDM]]), the South San Francisco maker of microfluidic instruments used to identify rare and valuable cells.

—San Diego’s CareFusion (NYSE: [[ticker:CFN]]) agreed to pay $150 million to acquire Rowa, a German maker of robotics used in pharmacies for the automated high-speed storage and retrieval of pre-packaged pharmaceutical products. CareFusion said the buyout offers an opportunity for the company to expand its Pyxis line of products in markets outside the United States.

OncoSec Medical, a three-year-old San Diego company developing a proprietary electroporation technology that’s intended to make cancer drugs more effective, raised $3 million through a private stock placement. The company trades on the over-the-counter bulletin board as ONCSD.

—San Diego-based Apricus Biosciences (NASDAQ: [[ticker:APRI]]) sold BioQuant, its contract research organization (CRO) subsidiary, to BioTox Sciences for $5 million in up-front and future earn-out payments and a potential to get as much as $20 million over the next 10 years. Apricus Bio said it retained all NexMed-related research conducted by Bio-Quant as well as BioQuant’s profitable diagnostic kit business. Apricus, which was previously a New Jersey life sciences company known as NexMed, moved to San Diego after it acquired BioQuant about eight months ago.

Author: Bruce V. Bigelow

In Memoriam: Our dear friend Bruce V. Bigelow passed away on June 29, 2018. He was the editor of Xconomy San Diego from 2008 to 2018. Read more about his life and work here. Bruce Bigelow joined Xconomy from the business desk of the San Diego Union-Tribune. He was a member of the team of reporters who were awarded the 2006 Pulitzer Prize in National Reporting for uncovering bribes paid to San Diego Republican Rep. Randy “Duke” Cunningham in exchange for special legislation earmarks. He also shared a 2006 award for enterprise reporting from the Society of Business Editors and Writers for “In Harm’s Way,” an article about the extraordinary casualty rate among employees working in Iraq for San Diego’s Titan Corp. He has written extensively about the 2002 corporate accounting scandal at software goliath Peregrine Systems. He also was a Gerald Loeb Award finalist and National Headline Award winner for “The Toymaker,” a 14-part chronicle of a San Diego start-up company. He takes special satisfaction, though, that the series was included in the library for nonfiction narrative journalism at the Nieman Foundation for Journalism at Harvard University. Bigelow graduated from U.C. Berkeley in 1977 with a degree in English Literature and from the Columbia University Graduate School of Journalism in 1979. Before joining the Union-Tribune in 1990, he worked for the Associated Press in Los Angeles and The Kansas City Times.